|
KMID : 1141420230280020226
|
|
Korean Journal of Healthcare-associated Infection Control Prevention
2023 Volume.28 No. 2 p.226 ~ p.232
|
|
|
A Study on the Status and Genetic Characteristics of Carbapenem Resistance of Clinical-derived Bacteria in Northern Gyeonggi Province
|
|
Lee Chan-Mi
Kim Kyung-A
Oh Sang-Heon
Jang Mi-Jung
You Su-Hyun
Park Han-Byeol
Ko Da-Jung
Kweon Bo-Yeon
|
|
|
Abstract
|
|
|
Background: Carbapenem-resistant Enterobacterales (CRE) is an infectious disease caused by an Enterobacteriaceae species resistant to one or more of the carbapenem antibiotics.
Methods: Strains collected in clinical trials from 2018 to 2022 in the northern Gyeonggi region were tested. CRE strain identification was performed using 16s rRNA sequencing or VITEK2 (BioMerieux, France). The antibiotic minimum inhibitory concentrations were confirmed using the broth microdilution method, and polymerase chain reaction was performed to detect carbapenemase (CPE) genes.
Results: Throughout the five-year period, CRE infections continued to spread in northern Gyeonggi Province, and the proportion of strains containing CPE genes also increased. The dominant strain causing communicable infection were K. pneumoniae, E. coli, and E. cloacae complex, and the CPE genes influencing infection were KPC, NDM, and OXA. The genotype distribution of CRE-positive species indicated that K. pneumoniae-KPC-2 was the most common. Carbapenem antibiotic resistance analysis revealed that the Ertapenem-Imipenem- Meropenem-Doripenem type, which is resistant to all four antibiotics, is the most common at 52.3%.
Conclusion: This study confirmed that CRE infection has continued to spread in medical institutions in northern Gyeonggi Province over the past five years. CRE can cause clinical infections with a variety of serious complications. In addition, patients with CRE have difficulty in treatment due to the limited availability of antibiotics. Continuous monitoring of the epidemic and patient management are necessary to prevent antibiotic resistance.
|
|
|
KEYWORD
|
|
|
Carbapenem-resistant Enterobacterales (CRE), Carbapenemase-producing Enterobacterales (CPE)
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|